Sunday, December 30, 2012

Repatriation next step PM Netanyahu Convenes Discussion on the Issue of Work Infiltrators from Africa

IMRA Saturday 29th December, 2012

PM Netanyahu Convenes Discussion on the Issue of Work Infiltrators from Africa (Communicated by the Prime Minister's Media Adviser) Prime Minister Benjamin Netanyahu, this afternoon (Monday, 24 December 2012), convened a discussion on the issue of progress in the process of repatriating illegal work infiltrators to their countries of origin. Hagai Hadas, who is responsible for repatriating infiltrators to their countries of origin in Afric...

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Source: http://www.middleeaststar.com/index.php/sid/211647247/scat/940f2bfd509e743b

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N.Y. Newspaper Announces it Will Publish More Names ... - The Blaze

Gannett?s Journal News Announces it Will Release More Names & Addresses of Gun OwnersApparently undeterred by retaliation from a pro-Second Amendment blogger, the editorial staff at Gannett?s ?Journal News? is at it again.

After creating an uproar for publishing the names and addresses of gun owners in New York?s Westchester and Rockland counties, ?Journal News? announced it would release and publish the names and addresses of permit holders in Putnam County, according to Reuters.

?Further names and addresses will be added as they become available to a map originally published on December 24 in the White Plains, New York-based Journal News,? the report notes.

The map was included in an article entitled ?The gun owner next door: What you don?t know about the weapons in your neighborhood,? that was released shortly after a shooting spree in Newtown, Conn., claimed 26 lives, including 20 children.

?Some 44,000 people are licensed to own pistols in the three counties, the newspaper said. Owners of rifles and shotguns do not need permits,? Reuters adds.

The newspaper?s decision to publish the names and addresses of permit holders has been met with both praise and criticism.

?Do you fools realize that you also made a map for criminals to use to find homes to rob that have no guns in them to protect themselves?? Rob Seubert of Silver Spring, Maryland, wrote on the newspaper?s web site. ?What a bunch of liberal boobs you all are.?

Meanwhile, Sen. Greg Ball (R-N.Y.) announced plans to introduce legislation that would keep the names and addresses of gun owners private except to law enforcement.

?The asinine editors at the Journal News have once again gone out of their way to place a virtual scarlet letter on law abiding firearm owners throughout the region,? the senator?s website reads.

Gannett?s Journal News Announces it Will Release More Names & Addresses of Gun Owners

After the newspaper launched its ?gun owners? map, pro-Second Amendment blogger Robert Cox retaliated by releasing a map with the names & addresses of ?Journal News? employees.

For her part, CynDee Royle, VP of news and editor, stands by the newspaper?s decision to publish private citizens? information.

?We knew publication of the database would be controversial, but we felt sharing as much information as we could about gun ownership in our area was important in the aftermath of the Newtown shootings,? she said.

But Al Tompkins, media critic for the Poynter Institute, writes that the newspaper failed to justify its decision to publish permit holders? personal information.

?If journalists could show flaws in the gun permitting system, that would be newsworthy,? he said. ?Or, for example, if gun owners were exempted from permits because of political connections, then journalists could better justify the privacy invasion.?

He continued, adding that he ?feared the dispute might prompt lawmakers to play to privacy fears,? as Reuters notes.

?The net effect of the abuse of public records from all sides may well be a public distaste for opening records, which would be the biggest mistake of all,? he said.

Follow Becket Adams (@BecketAdams) on Twitter

(H/T: Newser). Featured image courtesy Lohud.com.

Source: http://www.theblaze.com/stories/n-y-newspaper-announces-it-will-publish-more-names-addresses-of-gun-owners/

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Ouya starts shipping consoles to developers - AfterDawn

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Pinterest, the popular virtual pinboard, has received its first lawsuit. Theodore F. Schroeder of Ocean City, N.J., has sued the site this week, claiming misappropriation, unjust enrichment ....
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A Chinese court has ruled Apple must pay a tiny penalty to eight writers. The writers, along with two companies, had accused Apple of allowing their work to be made available for distribution ....

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Source: http://www.afterdawn.com/news/article.cfm/2012/12/30/ouya_starts_shipping_consoles_to_developers

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Saturday, December 29, 2012

withhold toddy: Home Crafts with Basic Office Supplies-spun2 | new ...

There is nothing more fun that getting together with the family and having a session of craft making. It teaches children to be creative and you can end up with some great things for your home. All you really need is basic office fitflop online supplies that you can buy at most supermarkets and you have the tools to create whatever your mind can conceive.

A good example of this is getting the children together to make Christmas decorations. All that is really needed in terms of office supplies is paper, a pair of scissors and a stapler. Get the children to cut the paper into little strips then draw their impressions of Christmas on them. From here you can take the strips and staple the ends together to make them into loops cheap nike nfl jerseys.

The trick is that you look the second one through the first before you staple it together. You can continue going until Fitflop Via best price you have a long enough chain of paper then just start a new one. You can even use this idea all year round to brighten up your children rooms. The paper you use can be simple white paper or even fancy coloured paper. Your local office supply store should stock all varieties of paper for you to choose from.

If decorations are not quite your thing why not try scrap booking? This is a great idea for getting your children to interact and create memories. Not only will you end up with a great photo album but your child can add to the book fitflops australia as they go along. They will be able to look back in years to come and see how many happy times they had with you.

The ideas for home crafts are literally endless and all you really need is the office supplies you can buy at most general stores. You could even take the whole thing a step higher and start creating home crafts to sell.

One good home craft that generally sells well is homemade picture frames. You will have to start out with a basic frame bought from the store but from here you can customize it in any way you like. From printing pictures and using decoupage to stick them onto the frames to making papier-mh?animals or people to give them a 3D effect, the ideas are as limited as your imagination.

If you feel that home crafts are something you would enjoy doing then take some time to browse the internet for some ideas. There are lots of sites that offer not only great ideas but also the blueprints to help you create your masterpiece.

You can easily get some office supplies from your local office store or even a supermarket. Whether you choose to go into it Cheap FitFlop Xosa sale online free shipping for self satisfaction or to create an extra income fitflop sale is irrelevant, the basic principles will always be the same. Take a little time, a dose of effort and some basic office supplies and you will be crafting in no time at all.

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Source: http://newcoolguys.wordpress.com/2012/12/24/home-crafts-with-basic-office-supplies-spun2/

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Source: http://uilybumy.posterous.com/home-crafts-with-basic-office-supplies-spun2

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Source: http://uodovogi.posterous.com/home-crafts-with-basic-office-supplies-spun2

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Source: http://withhold-toddy.blogspot.com/2012/12/home-crafts-with-basic-office-supplies.html

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Senate's Reid prepares bill with $250,000 tax-hike threshold

CHICAGO (Reuters) - Tiny fragments said to be from the manger that held the infant Jesus, the veil of his mother, Mary, and a thread from the cloak of St. Joseph will be displayed by a Roman Catholic church in Chicago when it celebrates its 155th anniversary on Sunday. The fragments, released by the Vatican in 1972, were a gift to the Holy Family Church from the Shrine of Our Lady of Pompeii, also in Chicago. Displaying them now has particular significance because of their association with Christmas, which marks the birth of Jesus. The Rev. Jeremiah J. ...

Source: http://news.yahoo.com/senates-reid-prepares-bill-250-000-tax-hike-235919380--business.html

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sannyasnews

I just came across Osho?s provocative words below?? And I am asking anyone with long? experience of Osho and Osho?s ashram/commune, (such as many of the contributors to Sannyasnews),? whether Osho is just here ?the speaker?,? as is often said speaking very well, but contrary wise on all manner of subjects to take his disciples beyond their egos ? and sometimes with the tongue very much in the cheek?? Or when He pronounces on such subjects,? can he be said in the normal sense to be standing behind his words??

?? Shantam

Osho: Premarital and Extramarital Relationships
Man is by nature polygamous. Monogamy is enforced on him. To satisfy his polygamous nature, man created prostitutes. Prostitution and Private Property are by-products of Marriage and Family. And this ugly institution of prostitution and possessing private properties will not disappear from the world unless marriage disappears.
Most of the marital problems arise because premarital and extramarital sex is denied. In a better human society premarital and extramarital sex should be appreciated.
Unless a man or a woman has lived in many pre-marital relationships there is no possibility of choosing a right partner. This is such a simple phenomenal! Unless you have experienced many women and men in your life, how can you choose who is going to be the right person to live with?
I am not against extra-marital relationships. Extra-marital relationships help marriage, they don?t destroy it. The people who are against them are really teaching you possessiveness in an indirect way. When I say I am not against extra-marital relationships I am teaching you non-possessiveness.
Extra-marital relationships are very significant, immensely helpful to psychological growth and maturity. In the new world, to which I have dedicated my whole life, there should be no marriage ? only lovers. And as long as they are pleased to be together, they can be together; and the moment they feel that they have been together too long, a little change will be good. All the psychologists are agreed on one point: couples who love each other should have a few love affairs once in a while. Those love affairs will renew their relationship, will refresh it. You will start seeing beauty and a greater intimacy again in your old lover. Intimacy is far more fulfilling than any sexual relationship can ever be.
If one allows nature without any inhibitions to take its own course, one transcends biology, body, mind, without any effort and can taste the ultimate bliss which is not dependent on your biology, body or mind. But we are full of inhibitions. If you are repressive, then you cannot transcend biological pulls naturally, without any effort. So, the first thing to be remembered is that nature is right.
To transform sexual energy into spirituality is my basic approach.

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Source: http://sannyasnews.org/now/archives/2428

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Friday, December 28, 2012

Hogadon Opening Day Announced!

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The City of Casper?s Hogadon Ski Area is pleased to announce the official opening day for the 2012-2013 season!

After anxiously awaiting some assistance from Mother Nature, the Hogadon team has been able to make enough snow to open for the season.

Opening day will be Sunday, December 30th with limited runs opening at Hogadon Ski Area. ?Open runs will include Bunny and Park.

Daily lift tickets will be available for just $13.00 until more runs are opened. Early season conditions exist and snow making will continue on open trails.

Due to the late start this season, Hogadon Ski Area will be open December 30th ? January 6th, seven days a week. After January 6th, the hours will go to the normal Wednesday through Sunday schedule.

This season, Hogadon season pass holders will benefit from ski agreements for discounted lift tickets at resorts including; Jackson Hole, Red Lodge Mountain Resort, Snow King and Snowy Range.

First-Time Hogadon Season Passes are available all season long for just $175.00 and can be purchased at the Casper Recreation Center or at Hogadon Ski Area.

The Hogadon team along with Mountain Sports and Casper Mountain Snow Sports School is excited to offer ?Learn to Ski/Snowboard Weekends? every Saturday and Sunday throughout the season. This program offers the opportunity to learn how to ski or snowboard for just $35.00. The ?Learn to Ski/Snowboard Weekends? include a lift ticket, a 2 hour lesson and equipment rental all for one great price. Children under 12 will also receive a free cup of hot cocoa when they take part in the program.

Be sure to stay tuned for information regarding the opening of additional runs. Check out the Hogadon Facebook page at www.facebook.com/hogadon, call 307-235-8499, or log on to www.hogadon.net for up to date information about opening day, ski agreements at partner resorts, or season passes!

Click Here to Win a Pair of Full Day Lift Tickets

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Source: http://k2radio.com/hogadon-opening-day-announced/

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Thatcher papers show fascination with Reagan visit

LONDON (AP) ? It is not often that the president of the United States needs to seek fashion advice.

But when Ronald Reagan was getting ready for a visit to England as a guest of Queen Elizabeth II in June 1982, his people had an important question for the Brits: Just what does one wear to go riding with the queen in the magnificent horse country surrounding Windsor Castle?

The answer: Something smart, but casual, of course. Riding boots, breeches and a turtleneck sweater would do fine ? no need for formal riding attire.

The fashion inquiry is but one tidbit contained in nearly 500 pages of formerly Confidential documents relating to the Reagan visit being made public Friday by Britain's National Archives. The dossier shows the British government ? led by Prime Minister Margaret Thatcher ? to be extraordinarily interested in pleasing the relatively new president on his two-day visit. British leaders also fretted that perennial cross-Channel rivals might triumph in the tug-of-war for presidential face time in a visit that had to be sandwiched between two summits on the European mainland.

The papers show that top Reagan adviser Michael Deaver had a way of annoying his British counterparts with last-minute changes and requests, and also surprised them with some of his objectives. Deaver, remembered as a shrewd image-builder, said he wanted Reagan to be photographed outside of formal venues, so he wouldn't be seen "exclusively in white tie" at palace functions, even suggesting that Reagan go to a village pub to soak up the atmosphere

There were raised eyebrows, and bruised feelings, when the White House failed to formally reply in a timely fashion to an official invitation from the queen ? the sort of invite that usually commands respect and a prompt reply the world over. The queen's invite was left to languish for weeks and weeks, something that the British believe is simply Not Done.

"It is really for the president to respond to her invitation, which he has not done personally, something that I have pointed out several times here," writes Nicholas Henderson, Britain's ambassador to Washington, in a memo to the British Foreign Office. "As you know those surrounding the president are not deliberately rude: It is simply that they are not well-organized and do not have experience of this sort of thing."

William F. Sittman, a special assistant to Reagan who was involved in planning the trip, told The Associated Press that it is possible the delay in responding to the queen was caused by first lady Nancy Reagan's insistence on consulting her astrologer before travel plans were finalized.

"You have to remember that Mrs. Reagan was very strict about his schedule, and she would consult her astrologer to see if this was the right time to travel," he said. "Sometimes she would back up departures."

The documents make clear that Europe's leaders were desperate for Reagan's attention at a time of high Cold War tensions. A memo from U.K. Cabinet Secretary Robert Armstrong on Feb. 5 expresses concern that a gala, summit-closing dinner at the palace of Versailles outside Paris could delay Reagan's arrival in London. But he warns against pressuring the Reagan entourage to skip the meal at Versailles' Hall of Mirrors because "that would not please the President of the French Republic."

Reagan's aides also worried the British by suggesting the president might have to skip the stop in London because accepting it might anger the Germans, who had offered a similar invitation. But feelings are smoothed over a bit when the Americans assure the British contingent that the Germans are not America's top priority.

"Eagleburger emphasized how much the president himself wanted to go to London," stresses one confidential memo from the British ambassador, referring to senior U.S. diplomat Lawrence Eagleburger. "There should be no doubt about that. Eagleburger also said that at the moment the Germans were not America's favorite allies."

The prospect of a chance to relax from international summitry with a bit of horseback riding with the queen seems to have helped carry the day for the Brits. Asked for the president's favorite type of horse, British planners are told simply that he wants a thoroughbred. He ended up riding Centennial, one of the queen's favorites, and wearing a perfectly fitted sports jacket above his sweater, going for an old-time Hollywood look he carried off with ease.

Much of the actual visit was devoted to pomp and pageantry, or to relaxation, but Reagan did make one speech of consequence. He became the first American president to address a meeting of both houses of Parliament and used the occasion to trumpet his distaste for the Soviet Union, calling it an economic catastrophe.

He said Marxism-Leninism would be left on the ash heap of history ? a prediction that would come to pass in the following decade.

Source: http://news.yahoo.com/thatcher-papers-show-fascination-reagan-visit-012217318.html

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Boatracs and KVH Industries Announce Strategic Partnership to ...

Boatracs and KVH Industries Announce Strategic Partnership to Provide End-to-End Global Broadband Solution to Maritime Market


San Diego, California (PRWEB) April 24, 2012

Boatracs Inc., a leader in providing integrated satellite communications and software solutions to the maritime industry, and KVH Industries, Inc., (Nasdaq: KVHI), a leading provider of in-motion satellite TV and communication systems, are collaborating to deliver an end-to-end mini-VSAT Broadband(SM) solution for small to medium sized businesses in the commercial workboat and fishing markets.

Sold through Boatracs, the Boatracs mini-VSAT Fleet Management Solution includes a TracPhone? V3 (to be called the Boatracs mini-VSAT V3), for global broadband connectivity as well as Boatracs web-based fleet management platform, Boatracs BTConnect?. Boatracs other maritime software products will also be available including BTForms, an electronic forms solution that automates and simplifies vessel data collection for operations, reporting and compliance record keeping. This new solution will be made available and supported through KVH and Boatracs loyal certified dealer network.

We are very excited to partner with an innovative top-tier company like KVH to integrate the award winning TracPhone? mini-VSAT Broadband system with Boatracs software solutions for the commercial maritime market, said Irwin Rodrigues, President and CEO of Boatracs. With increased regulatory compliance reporting and heightened competition, the needs of our customers have evolved dramatically over the past few years. Were seeing a growing need for simple yet highly effective integrated solutions that drive operational efficiencies, vessel productivity and compliance. The Boatracs mini-VSAT Fleet Management Solution meets these requirements in an affordable package through a single provider known in the industry for reliable service and a dedication to customer support.

The TracPhone V3 is the worlds smallest maritime VSAT antenna, designed for vessels as small as 30 feet. With airtime rates 1/10th the cost of L-band systems, the mini-VSAT network offers downloads as fast as 2Mbps at $ 0.99 per MB and phone calls worldwide at only $ 0.49 per minute. The benefits of the product have changed the game for satellite communications since being introduced by KVH in February 2011 due to its small size, fast data rates and affordable service. Powered by the largest VSAT network in the world, Boatracs unique offering will enable commercial maritime owners and operators to justify the need for reliable satellite communications on board their fleets of vessels.????

Boatracs BTConnect? is a web-based solution that integrates message and mapping functionality, providing access to fleet-wide data from anywhere on any device. With features such as route planning, custom landmarks and global map layers, BTConnect ties together the critical functions of visually managing a fleet with two-way messaging to improve dispatching, accelerate invoicing and streamline shore side operations.

KVH and Boatracs share the vision of making broadband accessible to small and medium fleets as critical software applications continue to drive the need for increased bandwidth, said Brent C. Bruun, Senior Vice President of Global Sales and Business Development at KVH Industries. By offering this combination of leading products and services in a turnkey package, workboat and commercial fishing companies can implement a high-speed voice and data service and be realizing the benefits of fleet management software immediately. We are pleased to partner with Boatracs as a demonstrated leader of integrated satellite communications solutions.

About Boatracs

Boatracs is the leading provider of integrated satellite communications and software solutions for the commercial maritime industry. Since 1990 Boatracs has been providing customers the industrys most proven, reliable, and simple solutions on the market. Boatracs now offers multiple communications solutions ranging from its core Qualcomm OmniTRACS product line to newer multi-mode broadband and voice capabilities, all powered by Boatracs web-based messaging and mapping software to provide access to fleet-wide data from anywhere on any device. Today Boatracs delivers products, services and 24/7/365 live customer support to offshore, inland, commercial fishing and government markets increasing operating efficiencies for thousands of vessels across North America. The company has offices in California and Louisiana. For more information, please visit us at: http://www.boatracs.com

About KVH Industries, Inc.

KVH Industries, Inc., is the leading provider of in-motion satellite TV and communications systems, having designed, manufactured, and sold more than 150,000 mobile satellite antennas for applications on vessels, vehicles, and aircraft. In March 2012, Euroconsult reported that KVH was the market share leader in global maritime VSAT. KVHs mission is to connect mobile customers around the globe with the same digital television entertainment, communications, and Internet services that they enjoy in their homes and offices. The company is based in Middletown, RI, with facilities in Illinois, Denmark, Norway, and Singapore. For more information please visit: http://www.kvh.com

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Source: http://www.cardifffilmfestival.co.uk/boatracs-and-kvh-industries-announce-strategic-partnership-to-provide-end-to-end-global-broadband-solution-to-maritime-market/

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Thursday, December 27, 2012

White House Dragging Feet On Car Tech Known For Saving Kids

SAN FRANCISCO (AP) - In the private hell of a mother's grief, the sounds come back to Judy Neiman. Her SUV door slamming. The slight bump as she backed up in the bank parking lot. The emergency room doctor's sobs as he said her 9-year-old daughter Sydnee, who previously had survived four open heart surgeries, would not make it this time after being backed over by her Mother's hulking SUV.

Her own cries of: How could I have missed seeing her?

The 53-year-old woman has sentenced herself to go on living in the awful stillness of her West Richland, Wash., home, where she makes a plea for what she wants since she can't have Sydnee back: More steps taken by the government and automakers to help prevent parents from accidentally killing their children, as she did a year ago this month.

"They have to do something, because I've read about it happening to other people. I read about it and I said, 'I would die if it happens to me,'" Neiman says. "Then it did happen to me."
There is, in fact, a law in place that calls for new manufacturing requirements to improve the visibility behind passenger vehicles to help prevent such fatal backing crashes, which the government estimates kill some 228 people every year - 110 of them children age 10 and under - and injures another 17,000.

Congress passed the measure with strong bipartisan backing, and Republican President George W. Bush signed it in 2008.

But almost five years later, the standards have yet to be mandated because of delays by the U.S. Department of Transportation, which faced a Feb. 28, 2011, deadline to issue the new guidelines for car manufacturers. Transportation Secretary Ray LaHood has pushed back that deadline three times - promising in February that the rules would be issued by year's end.

With still no action, safety advocates and anguished parents such as Neiman are asking: What's taking so long to remedy a problem recognized by government regulators and automakers for decades now?

"In a way, it's a death sentence, and for no good reason," said former Public Citizen president Joan Claybrook, who once directed the federal agency responsible for developing the rules.
The proposed regulations call for expanding the field of view for cars, vans, SUVs and pickup trucks so that drivers can see directly behind their vehicles when in reverse - requiring, in most cases, rearview cameras and video displays as standard equipment.

The National Highway Traffic Safety Administration, charged with completing the new standards, declined requests to discuss the delays. Spokeswoman Karen Aldana said the agency would not comment while the rulemaking process was ongoing but was on track to meet LaHood's latest cutoff date. In a letter to lawmakers in February, LaHood said his agency needed more time for "research and data analysis" to "ensure that the final rule is appropriate and the underlying analysis is robust."

Others insist the issue is money, and reluctance to put any additional financial burdens on an industry crippled by the economic crisis. Development of the new safety standards came even as the Obama administration was pumping billions of dollars into the industry as part of its bailout package.

"They don't want to look at anything that will cost more money for the automobile industry," said Packy Campbell, a former Republican state lawmaker from New Hampshire who lobbied for the law.

"This about money, but it is also about politics," says AOL Autos editor-in-chief David Kiley. "The Obama White House has been lobbied hard by automakers to either delay or eliminate the regulation because of costs the automakers are incurring to meet the new fuel economy regulations."

NHTSA has estimated that making rear cameras standard on every car would add $58 to $88 to the price of vehicles already equipped with dashboard display screens and $159 to $203 for those without them.

The Alliance of Automobile Manufacturers, a lobbying group that represents automakers, puts the total cost to the industry at about $2 billion a year that would largely be passed on to consumers. Last December, the group met with White House budget officials to propose a less expensive alternative: reserving cameras for vehicles with extra-large blind zones and outfitting the rest with curved, wide-angle exterior mirrors.

Before the delays, all new passenger vehicles were to carry cameras and video displays by September 2014. The industry has now asked for two more years after the final rules are published to reach full compliance.

Despite its resistance, the industry on its own has been installing rearview cameras, a feature first popularized two decades ago in Japan and standard on nearly 70 percent of new cars produced there this year. In the United States, 44 percent of 2012 models came with rear cameras standard, and 27 percent had them as options, according to the automotive research firm Edmunds. They come either as standard equipment on premium and luxury vehicles, or as options on lower priced vehicles.

Nine in 10 new cars had console screens available, according to market research firm iSuppli, which would put the price of adding a camera on the low end of the NHTSA's estimates.
These backing crashes are hardly a new phenomenon. Emergency room doctors, the National Centers for Disease Control and Prevention and the NHTSA have produced dozens of papers on the problem since the 1980s.

Researchers at the University of California, Irvine, started looking into the issue in the 1990s after noticing toddlers showing up in hospital databases of injured child pedestrians. They found that many of those children had been killed or hurt by vehicles backing out of home driveways.
In 1993, the NHTSA sponsored several studies that noted the disproportionate effect of backup accidents on child victims. One report explored sensors and cameras as possible solutions, noting the accidents "involve slow closing speeds and, thus, may be preventable." Still another 1993 report estimated that 100 to 200 pedestrians are killed each year from backing crashes, most of them children.

Three years later, Dee Norton, a reporter at The Seattle Times, petitioned the NHTSA to require improved mirrors on smaller commercial trucks and vans after his 3-year-old grandson was killed by a diaper delivery truck that backed over him.

Adding to the scrutiny were studies by Consumer Reports magazine, which started measuring "blind zones" to determine how far away a toddler-sized traffic cone had to be before a driver looking though the rear window could see it. The research found an overall trend of worsening rear visibility - due in part to designs favoring small windows and high trunk lines, said Tom Mutchler, the magazine's automotive engineer.

"Cameras are basically the only technology that is going to let you see something right behind the bumper," he said.

While no one doubts that cameras could help reduce deaths, they aren't regarded as a perfect solution either. One recent study by a researcher at Oregon State University found that only one in five drivers used a rearview camera when it was available, but 88 percent of those who did avoided striking a child-sized decoy.

In its proposed rule, the NHTSA estimated that rearview video systems could substantially reduce fatal backing crashes - by at least 95 a year - and result in at least 7,000 fewer injuries.

Judy Neiman's 2006 Cadillac Escalade didn't have any cameras installed. They weren't added as an optional package until the following model year. Instead, her vehicle was equipped with a "rear parking assist system" - bumper sensors, an alarm and lights that are supposed to go off within five feet of objects or people. Neither Neiman nor the 10-year-old neighbor boy who had accompanied her and her daughter to the bank on Dec. 8, 2011, would recall hearing any alert, according to a police report.

Sydnee was carrying her purple plastic piggy bank and account book, so she could deposit $5 from her weekly allowance. After the transaction, Neiman slid behind the wheel and waited for the children. She heard the door slam, then saw the boy sitting on the right side of the back seat as she put the car into reverse.

She figured Sydnee was seated behind the driver's seat. Instead, the boy had gotten in first, telling Sydnee to go around and get in from the left side. He would later tell a police investigator that the girl had dropped her piggy bank on her way around the SUV.

Even if she were upright, at 4-feet-3-inches tall, Sydnee would have been practically invisible through the rear window, the bottom edge of which was a few inches taller than she was.
As the first anniversary of her daughter's death passed, Neiman hoped that sharing her story might spare other parents from enduring the pain she feels every day.

She tortures herself by replaying a conversation she had with Sydnee the summer before she died. Her daughter always had taken her heart condition, a congenital defect, in stride. She never complained or showed fear, despite her many surgeries.

Then one night Sydnee started crying, and she wouldn't tell her mother what was troubling her until the next morning.

"She said, 'I don't want to die, Mom,' and when she died, that's all I could think about. She didn't want to die," Neiman says. "She survived four open heart surgeries. If God had taken her at that time, I could accept it. But who could take her with her being hit by my car? And my hitting her?"

Associated Press writer Joan Lowy in Washington, D.C., contributed to this story.

NOW CHECK OUT

Source: http://autos.aol.com/article/back-up-cameras-law/

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Tips For Understanding Car Insurance In The Current World ...

Posted by mikaza on December 27, 2012 in Business | Short Link

Auto insurance is a legal requirement for anybody who owns a car, in many states. You need to accomplish all of your research so that you don?t wind up paying to get a policy that does not work for you personally or losing profits to a policy scam. More often that not, they find that they are overpaying for car insurance and can usually get lower rates and premiums low-priced insurance protection. Selecting the best auto insurance plan can be described as a difficult task. With this in mind, deciding on the car insurance that suits you will be hard. If you have a car, you need to have insurance for it. If you end up needing automobile insurance don?t allow the plethora of companies and policies drive you crazy.

Before you purchase your next vehicle, consider the cost of insurance; you need to shop ahead before you invest in buy. Make sure you?re applying these expert tips to be able to get the most effective insurance package. Over-insuring will be a total waste of your money, while under-insuring will placed you at great personal financial risk if you get into an accident. What your auto insurer doesn?t know, however, can?t be applied for any discount, so be certain to demonstrate them your mileage each year car insurance queries and explanations. Even though you might see it as a manifestation of being a close friend to someone, do not allow someone else to drive your car that?s not in your policy. If you do not drive your vehicle often, this could wind up saving you a fair amount of money. Your credit card agreement will likely also not cover the insurance coverage related to the renting of the commercial truck. Therefore, there is no need in having high coverage in this instance.

When considering insurance to get a young driver, be certain that it is well known towards the insurance provider that they will have only access to one car. Some companies will increase your liability based around the cost of damages your vehicle could inflict: big vehicles cause a great deal of damage. This can be a great approach to save money. When filling in the application form for insurance you might be asked to divulge which of all your family members members are near driving age, or are of driving age. If they do, you may save a large amount of money should you pay for that car insurance annually instead.

Make certain that you must do some comparison-shopping before you decide to commit for an automobile insurance company. It?s worth asking your automobile insurance company about reductions for experienced drivers ? of course, providing you always drive safely. It will save that you simply good little time and money to adopt the time and energy to do this. You may be capable of make use of a lower premium quote from a different carrier as leverage to re-negotiate your existing rates, inside your favor.

Add your partner to your insurance policy. A higher deductible will mean a lower monthly payment, but more out of pocket inside the event of an accident. If you need to save lots of money, increase the deductible instead.

In conclusion, automobile insurance exists for cars, vans, trucks, motorcycles, and other automobiles. The insurance it really is these vehicles, compensates drivers in accidents. Those who drive without car insurance may face legal penalties, such as fines or jail. Apply the tips on this article today to obtain great automobile insurance that?s everything you?ll need it to be.

Tags: cheap automotive insurance rates

Source: http://valttiblogi.com/tips-for-understanding-car-insurance-in-the-current-world/

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Democrats face internal cliff hangups (Star Tribune)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/273104488?client_source=feed&format=rss

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Television section

For the week of Dec. 10-16

1. Sunday Night Football: San Francisco at New England, NBC, 23.23 million

2. "60 Minutes," CBS, 19.63 million

3. "NCIS," CBS, 17.65 million

4. "The Big Bang Theory," CBS, 16.74 million

5. "NCIS: Los Angeles," CBS, 15.12 million

6. Sunday Night NFL Pre-Kick, NBC, 14.62 million

7. "Person of Interest," CBS, 14.08 million

8. "Two and a Half Men," CBS, 13.34 million

9. "The Voice" (Monday), NBC, 12.33 million

10. "Criminal Minds," CBS, 12.01 million

Source: http://today.msnbc.msn.com/id/3032450/ns/today-entertainment/

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GDF Suez to Reload Small Scale LNG Carriers ... - LNG World News

GDF Suez to Reload Small Scale LNG Carriers at Zeebrugge Terminal

GDF SUEZ continues to develop its small scale liquefied natural gas (LNG) activities in North West Europe following the award by Fluxys of additional berthing and storage capacity long term rights at the Zeebrugge LNG terminal.

GDF SUEZ will have access to these capacities after the completion of the second jetty being constructed by Fluxys (expected in 2015). Those capacities will enable GDF SUEZ to reload small LNG carriers, such as LNG feeders and LNG bunkering vessels that will supply LNG as marine fuel for shipping companies.

LNG as a fuel for ships will develop in the future in a context of increasing pressure on maritime regulatoryconstraints on particle emissions in North Europe, as well as on fuel oil prices. Worldwide potential could reach more than 30 MTPA by 2025. LNG offers financial advantages and has various environmental benefits compared to diesel: CO2 emissions are 15-20% lower, the particulate matter content is 95% lower, the emission of sulphur is reduced by 90% and of NOx by 80%. Also, noise pollution of engines running on LNG is limited.

GDF SUEZ is already developing small scale LNG activities in Europe. Earlier this year, GDF SUEZ and GASNOR signed an LNG sales agreement for the supply of 7.5 TWh over a 12 year period. LNG volumes will be loaded first by trucks, from January 2013. In parallel, the Group is involved in the supply of LNG as fuel for trucks business through its affiliates Electrabel in Belgium, GDF SUEZ LNG Solutions in the Netherlands, and GNVert in France.

GDF SUEZ is one of the global LNG leaders and has a significant presence in regasification terminals around the world. Its LNG portfolio of 16 MTPA is sourced from 6 countries. The Group operates a fleet of 17 LNG carriers. The Group is the main LNG importer in the Atlantic Basin and the 2nd operator of LNG import terminals in Europe. In Western Europe, GDF SUEZ has access to long term regasification capacities in Zeebrugge, Belgium, Isle of Grain, the United Kingdom, Montoir-de-Bretagne and Fos sur-Mer, France.


LNG World News Staff, December 26, 2012

Source: http://www.lngworldnews.com/gdf-suez-to-reload-small-scale-lng-carriers-at-zeebrugge-terminal/

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Nscsfantasy Fast Track Bristol 2012rubbingsracing | Auto Racing

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Source: http://universodecharme.blogspot.com/2012/12/nscsfantasy-fast-track-bristol.html

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Source: http://meddle-fred.blogspot.com/2012/12/nscsfantasy-fast-track-bristol.html

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Wednesday, December 26, 2012

No threat to game sales from Connecticut shooting, says analyst ...

No threat to game sales from Connecticut shooting, says analyst

Cowan & Company analyst Doug Creutz is convinced that the Sandy Hook Elementary School shooting incident will have little to no impact on the sales of video games, even the ones depicting violence.

He assured the worried investors that video games will continue to sell well in the market irrespective of a new legislation, which seems highly likely with West Virginia Democrat senator Jay Rockefeller introducing a bill in the Congress for investigation of effects of violent games on children and their well-being.

Creutz also stated that the consumer backlash in the wake of tragic Connecticut shooting would be minor at most and will therefore not result in significant losses at all.

?We have received many questions from investors about the potential impact of the recent tragedy in Newtown on our covered universe of video game publisher stocks,? Creutz said. ?While this is a difficult issue to address due to the intense emotions surrounding the incident, we have attempted to present a summary of the relevant facts herein.?

The Cowan & Company analyst noted that the Supreme Court?s ruling last week, which deemed sales of violent games to children is in direct violation of the First Amendment, has laid down a solid ground for any attempts to regulate sales of video game to be struck down immediately.

Addressing the bill introduced by Rockefeller in Congress, Creutz contended that majority of the adults have already established an opinion about the effect of video game violence and real world violence and these opinions will not change that easily.

The bill introduced in Congress would task the National Academy of Sciences (NAS) to carry out a comprehensive study and investigation of the effects of violence in video games and other programming and their effects on the minds and well-being of children.

Creutz claimed that retailer checks with Amazon has revealed that first-person shooters such as Call of Duty: Black Ops II and Halo 4 are continuing to do really well in terms of market performance, thus making it quite obvious that the consumer behaviour has hardly been affected by the shooting at Sandy Hook Elementary School.

Source: http://blogs.bettor.com/No-threat-to-game-sales-from-Connecticut-shooting,-says-analyst-a210857

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Yemen violence kills 5 soldiers, 11 tribesmen

SANAA, Yemen (AP) ? Gunmen on motorbikes shot dead two Yemeni army officers in the country's capital Tuesday, and clashes between the military and tribal fighters loyal to al-Qaida in a northeastern province killed three soldiers and 11 tribesmen, officials said.

The violence came as al-Qaida's offshoot in Yemen, which the United States considers the most dangerous branch of the terror network, released a new video message calling on Yemeni Muslims to join jihad, or holy war, against America.

The two army officers were gunned down in separate parts of the capital, Sanaa, security officials said. The two were identified as Col. Fadhl Mohammed Jaber, who was shot outside his home, and Col. Saleem al-Gharbani, who was killed near a Sanaa military facility.

Similar attacks have killed several senior Yemeni military and intelligence officials this year. The government has blamed al-Qaida, saying the militants are waging a retaliation campaign over a U.S.-backed military offensive last summer that managed to push militants out of strongholds in several southern towns.

Military officials said clashes between the army and a tribe affiliated with al-Qaida in the northeastern province of Marib killed at least 11 tribesmen and three soldiers over the past 24 hours. The officials said a tribal chief, supported by al-Qaida elements and disenchanted over money allegedly owed to him by the government, has been leading the attacks on the army.

All officials spoke on condition of anonymity because they were not authorized to talk to reporters.

The province of Marib has seen a spate of clashes recently, mostly between the army and some tribesmen who maintain ties with al-Qaida. The tribesmen have also attacked oil pipelines and power stations in the province.

Two months ago, tribesmen blew up main electricity pylons and sabotaged an oil pipeline, protesting a death sentence against one of their members convicted of belonging to al-Qaida and killing security agents.

Some tribal chiefs are also suspected of being allied with former longtime President Ali Abdullah Saleh. Their attacks appeared to be aimed at undermining the new government.

Al-Qaida's Yemen branch, also known as al-Qaida in the Arabian Peninsula, released a video denouncing the United States for what it described as aggressive political and social policies against Islam.

In the video, reported Tuesday by the SITE Intelligence Group, which monitors militant activities, three Yemeni al-Qaida leaders ? including deputy leader Said al-Shihri and military commander Qassim al-Rimi ? urge Yemenis to join the jihad against an alleged American "occupation" of their country.

The video was produced by al-Qaida's local media arm, the al-Malahem Foundation.

___

Associated Press writer Maamoun Youssef in Cairo contributed to this report.

Source: http://news.yahoo.com/yemen-violence-kills-5-soldiers-11-tribesmen-132337106.html

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Tuesday, December 25, 2012

Building Your Dream Home in Mexico ? Different Styles Part 1

First of all, Happy Holidays, and I hope everyone?s enjoying and celebrating!

About a week or two ago, Tom shared a few articles on the first considerations and steps for building a home in Mexico.? Over these nice relaxing days between Christmas and New Years is? the perfect time to start considering your plans for buying?Mexico land for sale and building your dream!? Over the next couple of days I?m going to share some more detailed info on two of the important first steps ? choosing a style and then getting permits.

Mexico homes for saleChris Rauton, an experienced builder from the?Playa del Carmen real estate area, says ?Step 1 is to know what you want;? whether a property owner wants ?a luxury home on the beach with modern architectural features,? a charming colonial cottage or just about any other style, generally they?ll be able to go for the style of their dreams, provided that they start with this style in mind; (in some cases it may even be helpful to know the style they want when you choose your lot.)? While there is a great variety of styles, shapes and sizes available, the following are some of the favorites.

?

Mexico homes for saleModern Luxury

Many people who enjoy the cultural and historical richness of Mexico prefer to enjoy this lifestyle experience from a modern home with plenty large windows, open spaces, flying staircases, clean lines, soft colors, infinity pools, stainless steel and the like. People who prefer this style find that it enhances their relaxation in a pleasant, warm-weather lifestyle.

?

Mexico homes for saleClassic Colonial

One of Mexico?s architectural claims to fame is the classic colonial style which flourished for a few centuries before the war of independence, after which the more international and later modern influences took hold.? Archways, fountains, courtyards, high ceilings, domes, large wooden beams, elegant stonework, talavera tiles, bright colors and lots of flowers that bloom much of the year ? these and many other items define a style that let itself to the very relaxed lifestyle of Mexico?s upper class in days gone by.? While this social class and their lifestyle has all but disappeared, the architectural style continues to be used in private homes, still offering the same charm and relaxation.

Mexico homes for saleTomorrow we will look at the contemporary Mayan and indoor-outdoor styles.

Andy Welbourne, from London, Ontario, has been living in Playa del Carmen and working as a part of the team with Thomas Lloyd for 7 years. He has worked with many Canadians and Americans to assist in finding their dream home in the Mexican Caribbean; many of these clients have turned into great friendships. Contact Andy at (512) 879-6546.

The TOP Mexico Real Estate Network; ?Mexico?s Leading Network of Specialists for Finding and Purchasing Mexican Properties Safely!?

Mexico Real Estate Investment Kit

Source: http://www.topmexicorealestate.com/blog/2012/12/24/building-your-dream-home-in-mexico-different-styles-part-1/

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Automotive Service Technician Education For A New Profession ...

If you are looking for a Profession in auto repair, you will soon discover that automotive service technician Instruction is provided in trade schools, vocational schools and community colleges across the nation. Automotive service technician Instruction is ideal for these who appreciate utilizing their minds to resolve issues, and do not mind obtaining their hands dirty.

These days?s automotive repair expert should be much more than just an auto mechanic; they have to be nicely-trained specialists with solid Education in automotive service and repair and a lot of hands-on encounter. With the correct background and certified auto service Coaching, you may soon have the title of specialist automotive service technician.

The moment you start your automotive service technician Education, you will discover considerably far more than the essentials of vehicle upkeep and auto repair. A thorough automotive service technician course have to touch upon communications and organization practices, which will be specially valuable need to you make a decision to go into company for oneself.

Your practical Coaching will cover the specialized makes use of for electronic diagnostic gear, laptop or computer-based technical reference supplies, diagnostic computers and compression gauges. You will find out how diagnose the supply of engine or electrical dilemma(s) in automobiles, trucks, buses, and motorcycles, and accurately make a decision the variety of repairs essential. The auto service technician course will teach you to execute upkeep and repairs with classic hand tools, including screwdrivers, pliers, and wrenches, as effectively as power tools, specialized computers and hydraulic gear.

To reach the level of certified automotive service technician can take up to a year of study and practical knowledge. Some automotive service technician schools offer you an advanced two-year associate degree system, which would be quite useful Once in search of employment immediately after graduation. The moment you are a certified automotive repair technician, you will be topic to standard critique and recertification. You must be able to depend on your school update their curriculum to keep existing with emerging technologies, and to periodically provide refresher courses for operating technicians.

If you assume you are prepared to start automotive service repair Education, the very first step is to be certain that your selected school provides Automotive Service Excellence (ASE) Certification. ASE Certification assures that your school will provide you with Coaching that is complete and of high high quality.

To understand a lot more about automotive service technician Instruction, or even on-line automotive Education, go to our web site and submit a request to a couple of schools nowadays. You will soon be on your way to a new vocation in auto service and repair.

DISCLAIMER: Above is a Common OVERVIEW and might or could not reflect particular practices, courses and/or services related with ANY ONE certain school(s) that is or is not advertised on our site.

Copyright 2007 ? All rights reserved by Media Sure Communications, Inc.

Notice: Publishers are totally free to use this post on an ezine or site, supplied the write-up is reprinted in its entirety, such as copyright and disclaimer, and ALL hyperlinks stay intact and active.

Source: http://www.mapsmailedfree.com/380/automotive-service-technician-education-for-a-new-profession.html

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Monday, December 24, 2012

Mitchell: emigration seemed only way out | The Times

Andrew Mitchell talked of quitting Britain as he struggled to cope with the ?tsunami of vitriol? that engulfed him during the ?Plebgate? saga, it emerged yesterday.

The former Chief Whip told for the first time the depths of the emotional crisis triggered by his row with police officers in Downing Street.

He lost more than a stone in three weeks, couldn?t sleep, struggled to get out of bed and doubted his ability to emerge from the firestorm. ?As I faced the wall at three in the morning, I wondered if I could really go on facing much more of this,?

Source: http://www.thetimes.co.uk/tto/news/politics/article3639949.ece

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First goat genome sets a good example for facilitating de novo assembly of large genomes

Dec. 23, 2012 ? In a collaborative study published online today in Nature Biotechnology, researchers from Kunming Institute of Zoology, Chinese Academy of Sciences, BGI, and other institutes, have completed the first genome sequence of domestic goat by a robust approach integrated with next-generation sequencing (NGS) and whole-genome mapping (WGM) technologies. The goat genome is the first reference genome for small ruminant animals and may help to advance the understanding of distinct ruminants' genomic features from non-ruminant species. This work also yields a valuable experience for facilitating the de novo assemblies of large, complex genomes in the future.

Goats are recognized as an important member of the world livestock industry, and with many unique biological features. They are an important economic resource in many developing countries around the world, especially in China and India. However, despite their agricultural and biological importance, breeding and genetic studies of goats have been hampered by the lack of a high quality reference genome sequence. The goat genome sequence will be useful for facilitating the identification of SNP markers for marker-assisted breeding, and improving the utility of the goat as a biomedical model and bioreactor.

With the availability of next-generation sequencing (NGS), draft assemblies are easy to generate nowadays. However, to finish a sequence to the chromosome level remains a hard nut to crack. In this study, the results show that a single NGS platform, when combined with whole-genome mapping technology, could produce a finished assembly much faster and with high quality than other currently available mapping strategies such as BACs or FISH. Through this integrated approach, researchers obtained the ~2.66 Gb goat reference genome from a female Yunnan black goat.

Transposable elements (TEs) are major components of mammalian genomes and contribute to gene and/or genome evolution. The TEs in goat genome are similar to those of cattle, and contain large numbers of ruminant-specific repeats, such as SINE-tRNA and SINE-BovA. It is reported that SINE-BovA repeat expanded primarily in the cattle genome. However, in this study, researchers found the SINE-tRNA repeat expanded specifically in the goat genome.

Through constructing a phylogenetic tree among goats, cattle, horses, dogs, opossums and humans, researchers found the goat shared a common ancestor with cattle about 23 million years ago. Further comparison analysis revealed 44 rapidly evolving genes under positive selection, seven of which are immune-related genes and three are pituitary hormone or related genes. The immune-related genes identified also exist in cattle. The findings suggest that the rapid evolution of pituitary hormones may be related to the different features between goat and cattle in milk production, development rates of the fetus and/or hair variation.

The major histocompatibility complex (MHC) plays an important role in the immune system. In this study, the goat MHC was found to be located on chromosome 23 and contains two regions with length of 2.25 Mb and 360 kb, respectively. With the high quality genome assembly, further understanding of the goat MHC will be useful for immunological studies and vaccine development.

One of the distinguishing characteristics of mammals is the protective growth known as hair. It is produced by hair follicles within the skin, which could provide either protection (guard hairs) or insulation (underfur). The two major hair follicles include the primary hair follicle that produces only coat hair in all mammals, and the secondary hair follicle that can produce the cashmere or "fine hair" in certain mammals, including goats and antelopes. Despite a 2,500-year history and the extent of raw cashmere production, people are lack of understanding of the molecular mechanisms of cashmere formation and development.

Researchers conducted transcriptomic analysis on the primary and secondary follicles of a cashmere goat, revealing 51 genes that are differentially expressed between the two types of hair follicles. Keratin and keratin-associated proteins are the main structural proteins of hair fibers, determining the quality of fiber together. In the study, 29 keratin genes and 30 keratin-associated protein genes were detected in both types of follicles. Interestingly, they found two keratin genes and ten keratin-associated protein genes were consistently differentially expressed between primary and secondary hair follicles, suggesting that the keratin-associated protein genes may be more important in determining the structure of cashmere fibers. In addition to the keratin genes and keratin-associated protein genes, researchers also found several enzymes of amino acid biosynthesis, with implications in regulating primary hair growth and hair cycle.

Xun Xu, Deputy Director of BGI, said, "The goat reference genome is an important stepping stone in the molecular breeding of cashmere goats, and will help to advance the comparative studies on ruminants. The transcriptomic analysis on the primary and secondary follicles will open a new way for better improving the quality cashmere wool."

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Story Source:

The above story is reprinted from materials provided by BGI Shenzhen, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Yang Dong, Min Xie, Yu Jiang, Nianqing Xiao, Xiaoyong Du, Wenguang Zhang, Gwenola Tosser-Klopp, Jinhuan Wang, Shuang Yang, Jie Liang, Wenbin Chen, Jing Chen, Peng Zeng, Yong Hou, Chao Bian, Shengkai Pan, Yuxiang Li, Xin Liu, Wenliang Wang, Bertrand Servin, Brian Sayre, Bin Zhu, Deacon Sweeney, Rich Moore, Wenhui Nie, Yongyi Shen, Ruoping Zhao, Guojie Zhang, Jinquan Li, Thomas Faraut, James Womack, Yaping Zhang, James Kijas, Noelle Cockett, Xun Xu, Shuhong Zhao, Jun Wang, Wen Wang. Sequencing and automated whole-genome optical mapping of the genome of a domestic goat (Capra hircus). Nature Biotechnology, 2012; DOI: 10.1038/nbt.2478

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/CNn97tXK9DU/121223152629.htm

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Sunday, December 23, 2012

Internet Marketing Tools And Management: What Is A YouTube.Com ...

Sorry, Readability was unable to parse this page for content.

Source: http://www.name.com/blog/contentmarketing/2012/12/internet-marketing-tools-and-management-what-is-a-youtube-com-partner/

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Milwaukee Performing Arts Groups

With its diverse offerings of performing arts, Milwaukee is easily the cultural hub of the state of Wisconsin. From avant-garde theatre to classical ballet and choir, patrons of the arts will find a wide variety of performances to choose from throughout the year.? Learn more about performing arts groups in Milwaukee.

Source: http://milwaukee.about.com/b/2012/12/22/milwaukee-performing-arts-groups.htm

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Nutrient-sensing enzymes key to starvation response and survival in newborn mammals

Nutrient-sensing enzymes key to starvation response and survival in newborn mammals [ Back to EurekAlert! ] Public release date: 23-Dec-2012
[ | E-mail | Share Share ]

Contact: Nicole Rura
rura@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research

CAMBRIDGE, Mass. (December 23, 2012) In the perilous hours immediately after birth, a newborn mammal must survive the sudden loss of food supply from its mother. Under normal circumstances, newborns mount a metabolic response to ward off starvation until feeding occurs. This survival response involves a process of controlled breakdown of internal energetic sources known as autophagy. Although autophagy has been well documented, the key mechanistic regulators of autophagy in vivo have remained poorly understood.

Whitehead Institute researchers have discovered that a family of nutrient-sensing enzymes, dubbed Rag GTPases, modulates the activity of the mTORC1 protein complex, whose inhibition is essential for autophagy and survival in newborns. The finding, reported this week in the journal Nature, emerges from the lab of Whitehead Member David Sabatini, whose earlier in vitro studies showed that mTORC1 (for "mechanistic target of rapamycin complex 1") senses the presence of vital amino acids via interactions with Rag GTPases.

To assess the impact of this Rag GTPase-mTORC1 relationship in mammals, the lab generated mice genetically altered to continually express an active form of the GTPase RagA and compared them with wild-type mice. In normal mice, RagA is activated in the presence of nutrients, and turns on the mTORC1 pathway, which regulates organismal growth in response to nutrient availability. If the mice are deprived of nutrients, RagA is switched off, deactivating mTORC1 and initiating autophagy to tide the animal over until the next feeding. However, in the altered mice, RagA's continuous activity keeps mTORC1 active, despite a dearth of available nutrients. Instead of mTORC1 triggering autophagy, the animals' metabolisms remain unchanged, resulting in nutritional crisis and death.

"What happens to a newborn animal with the RagA enzyme always on is pretty shocking," says Sabatini, who is also a professor of biology at MIT and a Howard Hughes Medical Institute (HHMI) investigator. "A normal neonate animal within an hour after birth responds to that condition, but one with its RagA stuck 'on' doesn't, and it dies. It basically has a huge energetic and nutritional crisis because it can't make the adaption."

These striking results stunned Alejo Efeyan, a postdoctoral researcher in the Sabatini lab, and first author of the Nature that describes this work.

"We were surprised that there was no inhibition of this pathway independent of RagAthat there is no backup system," says Efeyan. "And that RagA is a more global nutrient sensor that goes beyond its known function as an amino acid sensor."

RagA's role as an amino acid sensor had been established in cultured cells by the Sabatini lab. Yet when Efeyan compared nutrient levels in fasting newborn RagA-active mice with those of fasting pups with normal RagA, not only amino acids were reduced in RagA-active animals, also glucose levels were dangerously low. The animals were unable to "sense" either of these reductions, so autophagy failed to initiate in the RagA-active pups, which all died within hours of birth.

This newly identified function for RagA suggests much remains unknown about the cell biology of nutrient sensing, an area of research that Sabatini and his lab continue to investigate.

###

This work was supported by National Institutes of Health (R01CA129105, R01 CA103866 and R37 AI047389), the American Federation for Aging, Starr Foundation, Koch Institute Frontier Research Program, the Ellison Medical Foundation, the Human Frontiers Science Program, the Jane Coffin Childs Memorial Fund for Medical Research, and the LAM Foundation.

Written by Nicole Giese Rura

David Sabatini's primary affiliation is with Whitehead Institute for Biomedical Research, where his laboratory is located and all his research is conducted. He is also a Howard Hughes Medical Institute investigator and a professor of biology at Massachusetts Institute of Technology.

Full Citation:

"Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival"

Nature, online on December 23, 2012.

Alejo Efeyan (1,2,3,4,5), Roberto Zoncu (1,2,3,4,5), Steven Chang (1,2,3,4,5), Iwona Gumper (6), Harriet Snitkin (6), Rachel L. Wolfson (1,2,3,4,5), Oktay Kirak (1,7), David D. Sabatini (6) and David M. Sabatini (1,2,3,4,5).

1. Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.

2. Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts 02142, USA.

3. Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.

4. David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

5. Howard Hughes Medical Institute, MIT, Cambridge, MA, 02139.

6. Department of Cell Biology, New York University School of Medicine, New York, NY 10016-6497, USA.

7. Present address: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037.



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Nutrient-sensing enzymes key to starvation response and survival in newborn mammals [ Back to EurekAlert! ] Public release date: 23-Dec-2012
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Contact: Nicole Rura
rura@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research

CAMBRIDGE, Mass. (December 23, 2012) In the perilous hours immediately after birth, a newborn mammal must survive the sudden loss of food supply from its mother. Under normal circumstances, newborns mount a metabolic response to ward off starvation until feeding occurs. This survival response involves a process of controlled breakdown of internal energetic sources known as autophagy. Although autophagy has been well documented, the key mechanistic regulators of autophagy in vivo have remained poorly understood.

Whitehead Institute researchers have discovered that a family of nutrient-sensing enzymes, dubbed Rag GTPases, modulates the activity of the mTORC1 protein complex, whose inhibition is essential for autophagy and survival in newborns. The finding, reported this week in the journal Nature, emerges from the lab of Whitehead Member David Sabatini, whose earlier in vitro studies showed that mTORC1 (for "mechanistic target of rapamycin complex 1") senses the presence of vital amino acids via interactions with Rag GTPases.

To assess the impact of this Rag GTPase-mTORC1 relationship in mammals, the lab generated mice genetically altered to continually express an active form of the GTPase RagA and compared them with wild-type mice. In normal mice, RagA is activated in the presence of nutrients, and turns on the mTORC1 pathway, which regulates organismal growth in response to nutrient availability. If the mice are deprived of nutrients, RagA is switched off, deactivating mTORC1 and initiating autophagy to tide the animal over until the next feeding. However, in the altered mice, RagA's continuous activity keeps mTORC1 active, despite a dearth of available nutrients. Instead of mTORC1 triggering autophagy, the animals' metabolisms remain unchanged, resulting in nutritional crisis and death.

"What happens to a newborn animal with the RagA enzyme always on is pretty shocking," says Sabatini, who is also a professor of biology at MIT and a Howard Hughes Medical Institute (HHMI) investigator. "A normal neonate animal within an hour after birth responds to that condition, but one with its RagA stuck 'on' doesn't, and it dies. It basically has a huge energetic and nutritional crisis because it can't make the adaption."

These striking results stunned Alejo Efeyan, a postdoctoral researcher in the Sabatini lab, and first author of the Nature that describes this work.

"We were surprised that there was no inhibition of this pathway independent of RagAthat there is no backup system," says Efeyan. "And that RagA is a more global nutrient sensor that goes beyond its known function as an amino acid sensor."

RagA's role as an amino acid sensor had been established in cultured cells by the Sabatini lab. Yet when Efeyan compared nutrient levels in fasting newborn RagA-active mice with those of fasting pups with normal RagA, not only amino acids were reduced in RagA-active animals, also glucose levels were dangerously low. The animals were unable to "sense" either of these reductions, so autophagy failed to initiate in the RagA-active pups, which all died within hours of birth.

This newly identified function for RagA suggests much remains unknown about the cell biology of nutrient sensing, an area of research that Sabatini and his lab continue to investigate.

###

This work was supported by National Institutes of Health (R01CA129105, R01 CA103866 and R37 AI047389), the American Federation for Aging, Starr Foundation, Koch Institute Frontier Research Program, the Ellison Medical Foundation, the Human Frontiers Science Program, the Jane Coffin Childs Memorial Fund for Medical Research, and the LAM Foundation.

Written by Nicole Giese Rura

David Sabatini's primary affiliation is with Whitehead Institute for Biomedical Research, where his laboratory is located and all his research is conducted. He is also a Howard Hughes Medical Institute investigator and a professor of biology at Massachusetts Institute of Technology.

Full Citation:

"Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival"

Nature, online on December 23, 2012.

Alejo Efeyan (1,2,3,4,5), Roberto Zoncu (1,2,3,4,5), Steven Chang (1,2,3,4,5), Iwona Gumper (6), Harriet Snitkin (6), Rachel L. Wolfson (1,2,3,4,5), Oktay Kirak (1,7), David D. Sabatini (6) and David M. Sabatini (1,2,3,4,5).

1. Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.

2. Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts 02142, USA.

3. Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.

4. David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

5. Howard Hughes Medical Institute, MIT, Cambridge, MA, 02139.

6. Department of Cell Biology, New York University School of Medicine, New York, NY 10016-6497, USA.

7. Present address: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037.



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Source: http://www.eurekalert.org/pub_releases/2012-12/wifb-nek122112.php

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